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cathepsin b inhibitor ca 074 methyl ester  (MedChemExpress)
94
MedChemExpress cathepsin b inhibitor ca 074 methyl ester
Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Cathepsin B Inhibitor Ca 074 Methyl Ester, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ca 074 methyl ester  (TargetMol)
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Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Ca 074 Methyl Ester, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
ca 074 methyl ester - by Bioz Stars, 2026-04
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ca 074 methyl ester  (MedChemExpress)
94
MedChemExpress ca 074 methyl ester
Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Ca 074 Methyl Ester, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ca 074 methyl ester/product/MedChemExpress
Average 94 stars, based on 1 article reviews
ca 074 methyl ester - by Bioz Stars, 2026-04
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ctsb inhibitor ca074me  (Selleck Chemicals)
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Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Ctsb Inhibitor Ca074me, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ca 074  (MedChemExpress)
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MedChemExpress ca 074
Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Ca 074, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cathepsin b inhibitor ca074  (MedChemExpress)
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Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Cathepsin B Inhibitor Ca074, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ca074 medchemexpress cat  (MedChemExpress)
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Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor <t>(Ca-074-Me).</t> Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.
Ca074 Medchemexpress Cat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor (Ca-074-Me). Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.

Journal: Redox Biology

Article Title: Lactate-driven ATP6V1B2 lactylation triggers asthmatic inflammation by linking lysosomal dysfunction to mitochondrial ROS-dependent pyroptosis

doi: 10.1016/j.redox.2026.104059

Figure Lengend Snippet: Effect of inhibiting Cathepsin B on mitochondrial dysfunction and tBid-Bax pathway. (A) Fluorescence imaging of mitochondrial membrane potential (JC-1) after administration of Cathepsin B inhibitor (Ca-074-Me). Scale bar: 100 μm. The ratio of red/green fluorescence intensity was quantified. (B) MitoSOX Red staining detects mitochondrial ROS. Scale bar: 100 μm. Quantification of MitoSOX Red fluorescence intensity is shown. (C) TEM images of mitochondrial ultrastructure. Scale bar: 2.0 μm. (D) Immunoblot analysis of Cathepsin B distribution in subcellular fractions (lysosome, cytosol, mitochondria). (E) Immunofluorescence staining of Cathepsin B (green) and LAMP1 (red). Scale bar: 100 μm. (F) Immunofluorescence staining of Cathepsin B (green) and MitoTracker (red). Scale bar: 40 μm. (G) Immunoblot analysis of Bid, tBid, XIAP, Bcl-2, Bcl-xL, and Bax protein expression. Data are expressed as Mean ± SEM. (n = 3 independent experiments) ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001; ns, not significant.

Article Snippet: In mechanistic studies, cells were pre-incubated with the following specific inhibitors for 2 h before stimulation: Ferrostatin-1, Necrosulfonamide, Z-VAD-FMK (10 μM), Z-IETD-FMK (10 μM), Z-DEVD-FMK (10 μM), Bafilomycin A1 (100 nM), Chloroquine (10 μM), 3-Methyladenine (3-MA, 3 mM), Cathepsin B inhibitor CA-074 Methyl Ester (Cat# HY-100350, MCE), BID inhibitor BI-6C9 (Cat# HY-103661, MCE), and calcium chelator BAPTA-AM (10 μM, Cat# HY-100545, MCE).

Techniques: Fluorescence, Imaging, Membrane, Staining, Western Blot, Immunofluorescence, Expressing